I put this info on Twitter as well as here in today's blog entry. Excuse the redundancy, but it seems really interesting and thus bears repeating.
I wondered across J.A Konrath's blog entry today and he discusses the state of Self Publishing. For anyone who doesn't know, Konrath is an already etablished print author, but his insight is still really interesting.
It's an eternal question for writers and it is getting to be a more commonly asked question as publication options, distribution options and marketing options become more and more varied.
I'm not taking a position on this one. It is a question for each writer/creative to decide when to seek acceptance by their industry's "gatekeeper" and when to go it alone instead.
This blog makes some compelling points though.