Read a great blog today about Self-pub versus Traditional written by Chuck Wendig. I can't recommend it enough! Great insight!
I can sum it up in a couple of quick works = "Do both"
Each year, write two novels. One for traditional publishing and one for self-pubbing. The Self-pub work can be hip, indie, niche or whatever. The traditional one should be...more traditional.
Still read the post though. Really insightful!